LRRC46

Across TCGA pan-cancer cohorts, LRRC46 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated LRRC46 data layer compared with 24 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher LRRC46 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated LRRC46 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

LUAD, LSCC, and UCEC are the cancer types where LRRC46 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	0.939	1.000	.003	21	view →
LSCC	DFS	Quartile	All	0.604	1.000	.008	15	view →
UCEC	DFS	Quartile	All	0.966	0.813	.044	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

LRRC46–LUAD (OS)

Open the LUAD breakdown →