LRRC46

Across TCGA patient cohorts, LRRC46 mutation is significantly associated with the RNA expression of many other genes, with 2,546 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRC46-associated genes across cancer lineages are LTF, SLC25A16, and ANKRD9. Each is linked with LRRC46 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC46-to-partner and partner-to-LRRC46 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LTF grouped by LRRC46-low versus LRRC46-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC46→partner) and Y-score (partner→LRRC46) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LTF →	-2.632	-3.459	.002	.005	3	2
UCEC	SLC25A16 →	+0.446	+3.716	.002	<.001	3	2
UCEC	ANKRD9 →	+0.552	+3.397	<.001	.004	3	2
UCEC	R3HCC1L →	+0.422	+3.467	.007	.002	3	2
UCEC	SOCS6 →	+0.556	+3.329	.006	.005	3	2
UCEC	LYNX1 →	-1.147	-4.000	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,546 associations by consensus.

LTF by LRRC46 expression — UCEC

Explore this box plot interactively →