LRRC46

Across TCGA patient cohorts, LRRC46 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRC46-associated genes across cancer lineages are ERK2, CD49b, and 14-3-3_beta. Each is linked with LRRC46 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC46-to-partner and partner-to-LRRC46 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by LRRC46-low versus LRRC46-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC46→partner) and Y-score (partner→LRRC46) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.264	+2.459	.004	.020	3	2
UCEC	CD49b →	-0.334	-3.156	.015	.018	3	2
UCEC	14-3-3_beta →	-0.110	-2.973	.023	.035	3	1
UCEC	A-Raf_pS299 →	-0.183	-3.321	.001	.010	3	1
UCEC	p70-S6K →	+0.187	+2.486	.044	.011	3	1
UCEC	PCNA →	+0.266	+2.459	.010	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

ERK2 by LRRC46 expression — UCEC

Explore this box plot interactively →