LRRC45

Across TCGA cell cohorts, LRRC45 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,098 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LRRC45-associated GO terms across cancer lineages are Regulation of transcription of nucleolar large rRNA by RNA polymerase I, Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I, and Replication fork processing. Each is linked with LRRC45 in more than 17 cancer types. Because this analysis shows association rather than direction, both LRRC45-to-partner and partner-to-LRRC45 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of transcription of nucleolar large rRNA by RNA polymerase I grouped by LRRC45-low versus LRRC45-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC45→partner) and Y-score (partner→LRRC45) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.178	+1.262	<.001	<.001	3	18
BONE	Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.162	+1.061	<.001	<.001	3	18
BONE	Replication fork processing →	+0.159	+1.781	<.001	<.001	3	16
PANCREAS	DNA replication proofreading →	+0.217	+1.140	<.001	<.001	3	16
BONE	DNA-templated DNA replication maintenance of fidelity →	+0.157	+1.846	<.001	<.001	3	16
BONE	DNA strand elongation involved in DNA replication →	+0.182	+1.282	.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,098 associations by consensus.

Regulation of transcription of nucleolar large rRNA by RNA polymerase I by LRRC45 expression — BONE

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