LRRC45

Across TCGA cell cohorts, LRRC45 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LRRC45-associated genes across cancer lineages are DEFA4, OR13G1, and RBMY1A1. Each is linked with LRRC45 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC45-to-partner and partner-to-LRRC45 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFA4 grouped by LRRC45-low versus LRRC45-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC45→partner) and Y-score (partner→LRRC45) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DEFA4 →	+0.040	+5.022	<.001	.002	3	1
LARGE_INTESTINE	OR13G1 →	+0.024	+4.415	<.001	.007	3	1
OVARY	RBMY1A1 →	+0.143	+5.807	<.001	.001	3	1
BLOOD_Leukemia	ZP1 →	+1.115	+3.523	<.001	.005	3	1
BLOOD_Leukemia	LRRC38 →	+1.140	+3.631	.003	.006	3	1
BLOOD_Leukemia	CHRNA9 →	+0.892	+3.491	.005	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

DEFA4 by LRRC45 expression — LARGE_INTESTINE

Explore this box plot interactively →