LRRC42

Across TCGA pan-cancer cohorts, LRRC42 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated LRRC42 data layer compared with 25 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher LRRC42 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated LRRC42 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUAD show a favorable association.

PDAC, CCRCC, and UCEC are the cancer types where LRRC42 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Quartile	All	0.257	0.604	.006	8	view →
CCRCC	DFS	Median	IV	0.164	0.861	.038	6	view →
UCEC	DFS	Quartile	II,III,IV	0.872	0.347	.037	4	view →
LUAD	DFS	Median	III,IV	1.000	0.498	.017	3	view →
GBM	DFS	Median	All	0.463	0.785	.025	1	view →
LSCC	DFS	Median	III,IV	0.882	1.000	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

LRRC42–PDAC (DFS)

Open the PDAC breakdown →