LRRC42

Across TCGA patient cohorts, LRRC42 mutation is significantly associated with the total protein of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRC42-associated genes across cancer lineages are JNK_pT183_Y185, ERK2, and ATM. Each is linked with LRRC42 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC42-to-partner and partner-to-LRRC42 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by LRRC42-low versus LRRC42-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC42→partner) and Y-score (partner→LRRC42) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.179	-3.000	.042	.036	3	1
UCEC	ERK2 →	+0.243	+3.321	.016	.010	2	1
UCEC	ATM →	-0.727	-3.321	.002	.010	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

JNK_pT183_Y185 by LRRC42 expression — UCEC

Explore this box plot interactively →