LRRC40

Across TCGA cell cohorts, LRRC40 mutation is significantly associated with the RNA expression of many other genes, with 360 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LRRC40-associated genes across cancer lineages are CBY1, PRSS54, and CRYM. Each is linked with LRRC40 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC40-to-partner and partner-to-LRRC40 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CBY1 grouped by LRRC40-low versus LRRC40-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC40→partner) and Y-score (partner→LRRC40) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CBY1 →	+0.674	+3.299	<.001	.004	3	1
LARGE_INTESTINE	PRSS54 →	+0.023	+2.760	.001	.003	3	1
LARGE_INTESTINE	CRYM →	+0.971	+3.212	.009	.006	3	1
LARGE_INTESTINE	TLE6 →	+0.994	+3.125	.001	.008	3	1
LARGE_INTESTINE	ASPN →	+0.031	+2.841	.005	.002	3	1
LARGE_INTESTINE	SEPSECS →	+0.760	+3.212	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 360 associations by consensus.

CBY1 by LRRC40 expression — LARGE_INTESTINE

Explore this box plot interactively →