LRRC4

Across TCGA pan-cancer cohorts, LRRC4 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated LRRC4 data layer compared with 27 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher LRRC4 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated LRRC4 expression acts as an unfavorable survival marker, although some lineages such as UCEC and BLCA show a favorable association.

HNSC, ESCA, and LUAD are the cancer types where LRRC4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.138	0.710	.001	24	view →
ESCA	OS	Median	II,III,IV	0.130	0.703	<.001	24	view →
LUAD	OS	Median	III,IV	0.223	0.677	.006	12	view →
LIHC	DFS	Median	All	0.118	0.555	.010	6	view →
UCEC	DFS	Median	All	0.938	0.828	.049	2	view →
BLCA	OS	Median	III,IV	1.000	0.351	.047	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

LRRC4–HNSC (OS)

Open the HNSC breakdown →