LRRC4

Across TCGA patient cohorts, LRRC4 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRC4-associated genes across cancer lineages are ERK2, IGFBP2, and PCNA. Each is linked with LRRC4 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC4-to-partner and partner-to-LRRC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by LRRC4-low versus LRRC4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC4→partner) and Y-score (partner→LRRC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.194	+2.321	.001	.005	3	2
UCEC	IGFBP2 →	-0.778	-2.321	<.001	<.001	3	2
UCEC	PCNA →	+0.195	+1.678	.003	.021	3	2
UCEC	Caspase-7-cleavedD198 →	+0.643	+1.522	<.001	.017	3	2
UCEC	C-Raf →	+0.137	+1.847	.002	.007	3	2
COAD	Smad1 →	+0.203	+2.832	.009	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

ERK2 by LRRC4 expression — UCEC

Explore this box plot interactively →