LRRC4

Across TCGA cell cohorts, LRRC4 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,351 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible LRRC4-associated GO terms across cancer lineages are Positive regulation of double-strand break repair via homologous recombination, Regulation of transcription of nucleolar large rRNA by RNA polymerase I, and Regulation of double-strand break repair. Each is linked with LRRC4 in more than 7 cancer types. Because this analysis shows association rather than direction, both LRRC4-to-partner and partner-to-LRRC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of double-strand break repair via homologous recombination grouped by LRRC4-low versus LRRC4-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC4→partner) and Y-score (partner→LRRC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Positive regulation of double-strand break repair via homologous recombination →	+0.071	+0.575	<.001	.003	3	8
SOFT_TISSUE	Regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.119	+1.042	.002	.005	3	8
SOFT_TISSUE	Regulation of double-strand break repair →	+0.062	+0.971	<.001	<.001	3	7
LUNG_SCLC	Positive regulation of osteoblast proliferation →	-1.021	-1.150	<.001	<.001	3	7
SOFT_TISSUE	Regulation of leukocyte proliferation →	-0.095	-1.403	<.001	<.001	3	7
SOFT_TISSUE	DNA damage checkpoint signaling →	+0.070	+1.493	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,351 associations by consensus.

Positive regulation of double-strand break repair via homologous recombination by LRRC4 expression — OVARY

Explore this box plot interactively →