LRRC37A7P

Across TCGA pan-cancer cohorts, LRRC37A7P RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of LRRC37A7P’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where LRRC37A7P RNA is repressed in tumor relative to normal tissue. In most cancer types LRRC37A7P is over-expressed in tumor, although a few such as KICH and HNSC show the opposite, repressed pattern.

KICH, KIRC, and HNSC are the cancer types where LRRC37A7P tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LRRC37A7P RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	III,IV	−1.555	<.001	11	view →
KIRC	Female	All	+1.427	<.001	11	view →
HNSC	Male	All	−1.018	<.001	11	view →
LUAD	Female	III,IV	−0.345	<.001	11	view →
BLCA	Female	III,IV	−0.449	.003	8	view →
BRCA	Female	All	−0.613	<.001	6	view →
THCA	Female	All	+0.464	<.001	6	view →
CHOL	All	All	−2.410	<.001	5	view →
COAD	Female	II,III,IV	−0.110	<.001	5	view →
LIHC	Female	All	−1.526	<.001	4	view →
KIRP	All	II,III,IV	−0.862	.007	4	view →
STAD	All	All	−0.281	.002	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

LRRC37A7P–KICH

Open the KICH breakdown →