Across TCGA pan-cancer cohorts, LRRC34P1 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of LRRC34P1’s most consistent transcriptional readouts.
The strongest signal is observed in thyroid carcinoma (THCA), where LRRC34P1 RNA is repressed in tumor relative to normal tissue. In most cancer types LRRC34P1 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.
THCA are the cancer types where LRRC34P1 tumor–normal differential expression is most reproducible.