LRRC32

Across TCGA patient cohorts, LRRC32 mutation is significantly associated with the RNA expression of many other genes, with 2,715 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRC32-associated genes across cancer lineages are PARP2, GEMIN2, and SRP54. Each is linked with LRRC32 in more than 4 cancer types. Because this analysis shows association rather than direction, both LRRC32-to-partner and partner-to-LRRC32 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PARP2 grouped by LRRC32-low versus LRRC32-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC32→partner) and Y-score (partner→LRRC32) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PARP2 →	+0.548	+2.736	<.001	<.001	3	4
LUAD	GEMIN2 →	+0.533	+2.217	.001	.001	3	4
LUAD	SRP54 →	+0.676	+2.876	<.001	.001	2	5
LUSC	VN1R70P →	+0.229	+4.520	<.001	.004	3	3
SKCM	UHRF1 →	+0.764	+3.919	<.001	<.001	3	3
UCEC	PRORP →	+0.288	+2.258	.004	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,715 associations by consensus.

PARP2 by LRRC32 expression — UCEC

Explore this box plot interactively →