LRRC32

Across TCGA patient cohorts, LRRC32 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRC32-associated genes across cancer lineages are ACC_pS79, Tuberin_pT1462, and ACC1. Each is linked with LRRC32 in more than 2 cancer types. Because this analysis shows association rather than direction, both LRRC32-to-partner and partner-to-LRRC32 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACC_pS79 grouped by LRRC32-low versus LRRC32-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC32→partner) and Y-score (partner→LRRC32) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACC_pS79 →	+0.292	+2.321	.041	.006	3	2
UCEC	Tuberin_pT1462 →	+0.276	+2.469	.003	.010	3	2
SKCM	ACC1 →	+0.257	+1.906	.038	.016	3	2
SKCM	C-Raf →	+0.159	+3.700	.004	.001	3	2
SKCM	Cyclin-B1 →	+0.392	+1.906	.016	.016	2	3
LUAD	p27 →	-0.162	-3.000	.013	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

ACC_pS79 by LRRC32 expression — UCEC

Explore this box plot interactively →