LRRC32

Across TCGA cell cohorts, LRRC32 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,424 significant associations in total. BONE shows the largest number of these associations.

The most reproducible LRRC32-associated GO terms across cancer lineages are ERAD pathway, COPII-coated vesicle budding, and Response to topologically incorrect protein. Each is linked with LRRC32 in more than 9 cancer types. Because this analysis shows association rather than direction, both LRRC32-to-partner and partner-to-LRRC32 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERAD pathway grouped by LRRC32-low versus LRRC32-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC32→partner) and Y-score (partner→LRRC32) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	ERAD pathway →	+0.057	+1.038	.009	.001	2	10
OESOPHAGUS	COPII-coated vesicle budding →	+0.118	+0.982	<.001	.001	3	9
BONE	Response to topologically incorrect protein →	+0.089	+2.220	<.001	<.001	3	8
BLOOD_Lymphoma	Negative regulation of respiratory burst involved in inflammatory response →	+0.111	+1.432	<.001	<.001	3	8
BLOOD_Lymphoma	Negative regulation of respiratory burst →	+0.111	+1.432	<.001	<.001	3	8
OESOPHAGUS	Endoplasmic reticulum to Golgi vesicle-mediated transport →	+0.088	+0.828	.004	.008	2	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,424 associations by consensus.

ERAD pathway by LRRC32 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →