LRRC31

Across TCGA patient cohorts, LRRC31 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRC31-associated genes across cancer lineages are Caspase-7-cleavedD198, JNK_pT183_Y185, and Notch1. Each is linked with LRRC31 in more than 2 cancer types. Because this analysis shows association rather than direction, both LRRC31-to-partner and partner-to-LRRC31 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by LRRC31-low versus LRRC31-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC31→partner) and Y-score (partner→LRRC31) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.738	+1.894	.003	.030	3	3
UCEC	JNK_pT183_Y185 →	-0.224	-3.700	.001	.001	3	2
UCEC	Notch1 →	+0.171	+2.472	.004	.010	3	2
UCEC	S6_pS240_S244 →	+0.629	+2.222	<.001	.011	3	2
UCEC	Shc_pY317 →	-0.154	-2.321	.017	.034	3	2
SKCM	PI3K-p85 →	+0.411	+2.820	<.001	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

Caspase-7-cleavedD198 by LRRC31 expression — UCEC

Explore this box plot interactively →