Across TCGA patient cohorts, LRRC30 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRC30-associated genes across cancer lineages are VHL, PDK1_pS241, and Smad4. Each is linked with LRRC30 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC30-to-partner and partner-to-LRRC30 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC30→partner) and Y-score (partner→LRRC30) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VHL →	-1.035	-2.321	<.001	.006	3	2
SKCM	PDK1_pS241 →	-0.184	-2.321	.001	.005	3	2
SKCM	Smad4 →	+0.109	+1.908	.006	.026	3	2
UCEC	Fibronectin →	-0.273	-2.575	.044	.010	3	1
UCEC	JNK2 →	+0.256	+3.026	.001	.018	3	1
UCEC	MSH2 →	-0.216	-2.449	.023	.019	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

Exploration

LRRC30 survival (RNA) · tumor vs normal (RNA) · all LRRC30 data types