LRRC29

Across TCGA patient cohorts, LRRC29 mutation is significantly associated with the RNA expression of many other genes, with 421 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRC29-associated genes across cancer lineages are MIR139, DNAAF1, and LRRK1. Each is linked with LRRC29 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC29-to-partner and partner-to-LRRC29 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR139 grouped by LRRC29-low versus LRRC29-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC29→partner) and Y-score (partner→LRRC29) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR139 →	+0.157	+3.829	<.001	.008	3	2
UCEC	DNAAF1 →	-1.137	-3.692	.005	.001	3	1
UCEC	LRRK1 →	-0.490	-3.451	.009	.005	3	1
UCEC	VPS37A →	+0.496	+3.459	.009	.005	3	1
UCEC	BAG4 →	+0.550	+2.243	.007	.006	3	1
UCEC	C12orf43 →	+0.311	+3.354	.004	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 421 associations by consensus.

MIR139 by LRRC29 expression — UCEC

Explore this box plot interactively →