LRRC29

Across TCGA patient cohorts, LRRC29 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRC29-associated genes across cancer lineages are eIF4G, FoxM1, and JNK_pT183_Y185. Each is linked with LRRC29 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC29-to-partner and partner-to-LRRC29 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4G grouped by LRRC29-low versus LRRC29-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC29→partner) and Y-score (partner→LRRC29) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4G →	+0.367	+3.321	.024	.010	3	1
UCEC	FoxM1 →	+0.295	+2.817	.029	.036	3	1
UCEC	JNK_pT183_Y185 →	-0.275	-3.308	.001	.010	3	1
UCEC	MAPK_pT202_Y204 →	-0.728	-3.321	.003	.010	3	1
UCEC	mTOR_pS2448 →	-0.187	-2.980	.016	.036	3	1
UCEC	Myosin-IIa_pS1943 →	+0.252	+2.183	.019	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

eIF4G by LRRC29 expression — UCEC

Explore this box plot interactively →