LRRC28

Across TCGA pan-cancer cohorts, LRRC28 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated LRRC28 data layer compared with 29 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher LRRC28 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated LRRC28 expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

LSCC and HNSC are the cancer types where LRRC28 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	All	0.917	0.459	.021	10	view →
HNSC	DFS	Median	II,III,IV	0.840	1.000	.041	5	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

LRRC28–LSCC (DFS)

Open the LSCC breakdown →