LRRC28

Across TCGA patient cohorts, LRRC28 mutation is significantly associated with the RNA expression of many other genes, with 3,741 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRC28-associated genes across cancer lineages are RN7SL847P, NFYBP1, and SMARCE1P2. Each is linked with LRRC28 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC28-to-partner and partner-to-LRRC28 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL847P grouped by LRRC28-low versus LRRC28-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC28→partner) and Y-score (partner→LRRC28) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RN7SL847P →	+0.260	+5.010	<.001	.009	3	2
UCEC	NFYBP1 →	+0.218	+2.001	<.001	.005	3	2
UCEC	SMARCE1P2 →	+0.144	+2.534	.003	.001	3	2
COAD	OR5D3P →	+0.084	+5.917	<.001	.001	3	1
COAD	RN7SKP153 →	+0.144	+4.516	.007	.009	3	1
COAD	RNA5SP428 →	+1.115	+4.681	.005	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,741 associations by consensus.

RN7SL847P by LRRC28 expression — CESC

Explore this box plot interactively →