LRRC28

Across TCGA cell cohorts, LRRC28 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,419 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LRRC28-associated GO terms across cancer lineages are Circadian sleep/wake cycle, Mitotic cytokinesis, and Golgi organization. Each is linked with LRRC28 in more than 9 cancer types. Because this analysis shows association rather than direction, both LRRC28-to-partner and partner-to-LRRC28 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Circadian sleep/wake cycle grouped by LRRC28-low versus LRRC28-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC28→partner) and Y-score (partner→LRRC28) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Circadian sleep/wake cycle →	+0.152	+1.095	<.001	<.001	3	9
OESOPHAGUS	Mitotic cytokinesis →	+0.092	+0.911	.003	.004	1	10
STOMACH	Golgi organization →	+0.069	+0.712	.002	.001	3	8
STOMACH	Ubiquitin-dependent protein catabolic process via the N-end rule pathway →	+0.095	+0.817	.002	.002	3	8
STOMACH	Response to L-leucine →	+0.097	+0.974	.001	<.001	3	7
PANCREAS	Inositol phosphate metabolic process →	+0.046	+0.636	.003	.006	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,419 associations by consensus.

Circadian sleep/wake cycle by LRRC28 expression — BLOOD_Lymphoma

Explore this box plot interactively →