LRRC27

Across TCGA patient cohorts, LRRC27 mutation is significantly associated with the RNA expression of many other genes, with 1,971 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRC27-associated genes across cancer lineages are MIR6803, TAF9, and MIR6864. Each is linked with LRRC27 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC27-to-partner and partner-to-LRRC27 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6803 grouped by LRRC27-low versus LRRC27-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC27→partner) and Y-score (partner→LRRC27) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MIR6803 →	+0.503	+4.798	<.001	.006	3	2
UCEC	TAF9 →	+0.598	+2.700	<.001	<.001	3	2
UCEC	MIR6864 →	+0.536	+1.546	<.001	.003	3	2
UCEC	SRCIN1 →	-0.560	-1.839	.002	.008	3	2
SKCM	RNU2-19P →	+0.072	+4.816	<.001	.001	3	2
CESC	MIR4309 →	+0.369	+5.342	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,971 associations by consensus.

MIR6803 by LRRC27 expression — LUAD

Explore this box plot interactively →