LRRC27

Across TCGA patient cohorts, LRRC27 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRC27-associated genes across cancer lineages are PCNA, Rad50, and MEK1. Each is linked with LRRC27 in more than 2 cancer types. Because this analysis shows association rather than direction, both LRRC27-to-partner and partner-to-LRRC27 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by LRRC27-low versus LRRC27-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC27→partner) and Y-score (partner→LRRC27) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PCNA →	+0.215	+3.000	.032	.035	3	3
UCEC	Rad50 →	-0.195	-1.502	.028	.030	3	3
UCEC	MEK1 →	+0.388	+2.321	.003	.005	3	2
UCEC	ATM →	-0.489	-1.986	.003	.029	3	2
UCEC	Caspase-7-cleavedD198 →	+0.600	+1.847	.005	.008	3	2
COAD	Lck →	+0.432	+2.832	.009	.035	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

PCNA by LRRC27 expression — SKCM

Explore this box plot interactively →