LRRC27

Across TCGA cell cohorts, LRRC27 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LRRC27-associated genes across cancer lineages are CST8, LRRC52, and OR10C1. Each is linked with LRRC27 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC27-to-partner and partner-to-LRRC27 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CST8 grouped by LRRC27-low versus LRRC27-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC27→partner) and Y-score (partner→LRRC27) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CST8 →	+0.021	+4.415	<.001	.007	3	1
LARGE_INTESTINE	LRRC52 →	+0.021	+4.415	<.001	.007	3	1
LARGE_INTESTINE	OR10C1 →	+0.017	+4.415	<.001	.007	3	1
LARGE_INTESTINE	IQCF6 →	+0.322	+4.467	<.001	.004	3	1
LARGE_INTESTINE	KRTAP10-1 →	+0.009	+4.415	<.001	.007	3	1
BLOOD_Leukemia	GSG1L2 →	+0.058	+5.969	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

CST8 by LRRC27 expression — LARGE_INTESTINE

Explore this box plot interactively →