Across TCGA pan-cancer cohorts, LRRC26 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated LRRC26 data layer compared with 1 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher LRRC26 RNA is associated with better overall survival. In most high-consensus cancer types, elevated LRRC26 expression acts as an unfavorable survival marker, although some lineages such as UCEC and STAD show a favorable association.

UCEC, STAD, and UCS are the cancer types where LRRC26 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	All	0.791	0.557	<.001	108	view →
STAD	DFS	Median	IV	0.575	0.124	<.001	93	view →
UCS	OS	Tertile	II,III,IV	0.204	0.638	.002	72	view →
COAD	DFS	Median	All	0.824	0.741	.007	30	view →
DLBC	DFS	Median	III,IV	0.984	0.294	.003	27	view →
ESCA	DFS	Median	II,III,IV	0.293	1.000	.002	24	view →
LUAD	DFS	Tertile	IV	0.350	0.892	.010	18	view →
PCPG	DFS	Quartile	All	0.717	0.960	.003	18	view →
ACC	DFS	Tertile	All	0.331	0.687	.009	17	view →
THCA	DFS	Quartile	III,IV	0.700	0.866	.016	17	view →
LGG	OS	Tertile	All	0.705	0.391	.001	17	view →
HNSC	OS	Median	All	0.800	0.709	.006	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

Exploration

Same gene, other analysis: LRRC26 tumor-vs-normal RNA expression · all LRRC26 data types