LRRC25

Across TCGA pan-cancer cohorts, LRRC25 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated LRRC25 data layer compared with 22 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher LRRC25 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated LRRC25 expression acts as an unfavorable survival marker, although some lineages such as LSCC and OV show a favorable association.

PDAC, COAD, and CCRCC are the cancer types where LRRC25 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	All	0.278	0.617	.004	21	view →
COAD	DFS	Median	All	0.847	1.000	.031	18	view →
CCRCC	DFS	Median	III,IV	0.428	0.741	.020	11	view →
LSCC	OS	Quartile	III,IV	0.970	0.570	.029	8	view →
OV	DFS	Median	All	0.884	0.604	.021	4	view →
GBM	OS	Quartile	All	0.254	0.588	.021	2	view →
HNSC	DFS	Median	II,III,IV	0.907	0.983	.045	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

LRRC25–PDAC (DFS)

Open the PDAC breakdown →