LRRC20

Across TCGA patient cohorts, LRRC20 mutation is significantly associated with the total protein of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRC20-associated genes across cancer lineages are Notch1, VHL, and Cyclin-B1. Each is linked with LRRC20 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC20-to-partner and partner-to-LRRC20 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by LRRC20-low versus LRRC20-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC20→partner) and Y-score (partner→LRRC20) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.304	+2.817	<.001	.036	3	1
UCEC	VHL →	-1.206	-3.000	.002	.036	3	1
UCEC	Cyclin-B1 →	+0.888	+3.000	.006	.037	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

Notch1 by LRRC20 expression — UCEC

Explore this box plot interactively →