Across TCGA patient cohorts, LRRC19 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRC19-associated genes across cancer lineages are EGFR_pY1173, JNK2, and mTOR_pS2448. Each is linked with LRRC19 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC19-to-partner and partner-to-LRRC19 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC19→partner) and Y-score (partner→LRRC19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1173 →	+0.087	+1.933	.006	.009	3	2
UCEC	JNK2 →	+0.251	+2.348	.001	.018	3	2
UCEC	mTOR_pS2448 →	-0.166	-3.446	.005	.005	3	2
UCEC	VHL →	-1.070	-2.222	<.001	.010	3	2
UCEC	eEF2 →	+0.363	+3.321	.011	.009	3	1
UCEC	EGFR_pY1068 →	-0.303	-3.087	.002	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

Exploration

LRRC19 survival (RNA) · tumor vs normal (RNA) · all LRRC19 data types