LRRC18

Across TCGA patient cohorts, LRRC18 protein abundance is significantly associated with the RNA expression of many other genes, with 281 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible LRRC18-associated genes across cancer lineages are RSPH14, PCYT1B, and TSNAXIP1. Each is linked with LRRC18 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC18-to-partner and partner-to-LRRC18 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LRRC18 versus RSPH14 in LUAD, with a Pearson correlation of 0.65.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC18→partner) and Y-score (partner→LRRC18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RSPH14 →	+1.056	+0.597	.001	.003	3	1
LUAD	PCYT1B →	+0.587	+0.526	.006	.005	3	1
LUAD	TSNAXIP1 →	+0.765	+0.630	.004	.002	3	1
LUAD	GSDMD →	-0.553	-0.470	<.001	.001	3	1
LUAD	PRR4 →	+0.913	+0.443	.006	.009	3	1
LUAD	RSPH4A →	+1.501	+0.615	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 281 associations by consensus.

LRRC18 vs RSPH14 — LUAD

Explore this scatter interactively →