LRRC18

Across TCGA patient cohorts, LRRC18 mutation is significantly associated with the RNA expression of many other genes, with 1,774 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRC18-associated genes across cancer lineages are RPL12P43, SNORA36C, and MIR6859-3. Each is linked with LRRC18 in more than 2 cancer types. Because this analysis shows association rather than direction, both LRRC18-to-partner and partner-to-LRRC18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL12P43 grouped by LRRC18-low versus LRRC18-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC18→partner) and Y-score (partner→LRRC18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RPL12P43 →	+0.093	+4.685	<.001	.007	3	3
LGG	SNORA36C →	+0.324	+6.632	<.001	.001	3	3
SKCM	MIR6859-3 →	+0.093	+2.326	<.001	.008	3	2
UCEC	GPATCH11 →	+0.517	+4.098	<.001	<.001	3	2
UCEC	BUB3 →	+0.593	+3.741	<.001	<.001	3	2
UCEC	EME1 →	+0.626	+3.364	.002	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,774 associations by consensus.

RPL12P43 by LRRC18 expression — BLCA

Explore this box plot interactively →