LRRC18

Across TCGA cell cohorts, LRRC18 RNA expression is significantly associated with the go_rna of many other GO terms, with 90 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible LRRC18-associated GO terms across cancer lineages are SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, Fc receptor signaling pathway, and Response to ether. Each is linked with LRRC18 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC18-to-partner and partner-to-LRRC18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SCF-dependent proteasomal ubiquitin-dependent protein catabolic process grouped by LRRC18-low versus LRRC18-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC18→partner) and Y-score (partner→LRRC18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process →	+0.028	+0.300	.001	.002	3	2
BLOOD_Lymphoma	Fc receptor signaling pathway →	+0.051	+0.386	.002	.008	3	2
BLOOD_Lymphoma	Response to ether →	-0.150	-0.293	<.001	.001	3	2
BLOOD_Leukemia	Smooth muscle cell migration →	-0.185	-0.139	<.001	.008	3	1
BLOOD_Leukemia	L-lysine catabolic process →	+0.137	+0.194	<.001	.006	3	1
BLOOD_Leukemia	Replication-born double-strand break repair via sister chromatid exchange →	-0.054	-0.155	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 90 associations by consensus.

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process by LRRC18 expression — BLOOD_Leukemia

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