LRRC17

Across TCGA patient cohorts, LRRC17 mutation is significantly associated with the RNA expression of many other genes, with 796 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRC17-associated genes across cancer lineages are DEFB108F, CIDECP1, and RNU6-178P. Each is linked with LRRC17 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC17-to-partner and partner-to-LRRC17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFB108F grouped by LRRC17-low versus LRRC17-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC17→partner) and Y-score (partner→LRRC17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	DEFB108F →	+0.146	+5.040	<.001	.002	3	2
UCEC	CIDECP1 →	+0.423	+2.238	<.001	.006	3	2
UCEC	RNU6-178P →	+0.532	+2.189	.002	.002	3	2
UCEC	IGHV3-66 →	+1.543	+3.258	<.001	<.001	3	2
UCEC	ZNF778 →	+0.484	+2.378	<.001	.003	3	2
UCEC	REXO1 →	+0.450	+2.087	.002	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 796 associations by consensus.

DEFB108F by LRRC17 expression — BLCA

Explore this box plot interactively →