LRRC17

Across TCGA patient cohorts, LRRC17 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRC17-associated genes across cancer lineages are TIGAR, Caspase-7-cleavedD198, and EGFR_pY1068. Each is linked with LRRC17 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC17-to-partner and partner-to-LRRC17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TIGAR grouped by LRRC17-low versus LRRC17-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC17→partner) and Y-score (partner→LRRC17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TIGAR →	+0.212	+2.348	<.001	.003	3	2
UCEC	Caspase-7-cleavedD198 →	+0.529	+2.189	.030	.034	3	2
UCEC	EGFR_pY1068 →	-0.225	-1.807	.029	.027	3	1
UCEC	MEK1 →	+0.482	+2.321	.001	.006	3	1
UCEC	MSH2 →	-0.236	-2.973	.013	.035	3	1
UCEC	PCNA →	+0.224	+3.169	.012	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

TIGAR by LRRC17 expression — UCEC

Explore this box plot interactively →