LRRC17

Across TCGA cell cohorts, LRRC17 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,282 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible LRRC17-associated GO terms across cancer lineages are Regulation of oxidative stress-induced intrinsic apoptotic signaling pathway, Negative regulation of syncytium formation by plasma membrane fusion, and Cellular response to transforming growth factor beta stimulus. Each is linked with LRRC17 in more than 6 cancer types. Because this analysis shows association rather than direction, both LRRC17-to-partner and partner-to-LRRC17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of oxidative stress-induced intrinsic apoptotic signaling pathway grouped by LRRC17-low versus LRRC17-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC17→partner) and Y-score (partner→LRRC17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Regulation of oxidative stress-induced intrinsic apoptotic signaling pathway →	+0.081	+3.309	.001	<.001	3	7
SKIN	Negative regulation of syncytium formation by plasma membrane fusion →	+0.091	+2.248	<.001	<.001	3	7
SKIN	Cellular response to transforming growth factor beta stimulus →	+0.065	+1.830	<.001	<.001	3	6
CNS	Vesicle-mediated transport to the plasma membrane →	+0.035	+2.830	.009	<.001	3	6
SOFT_TISSUE	Endodermal cell differentiation →	+0.192	+3.338	<.001	<.001	3	6
SOFT_TISSUE	P granule organization →	-0.762	-2.241	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,282 associations by consensus.

Regulation of oxidative stress-induced intrinsic apoptotic signaling pathway by LRRC17 expression — SOFT_TISSUE

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