LRRC17

Across TCGA cell cohorts, LRRC17 mutation is significantly associated with the drug of many other genes, with 24 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LRRC17-associated genes across cancer lineages are CCT007093, LCL161, and Zoledronate. Each is linked with LRRC17 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC17-to-partner and partner-to-LRRC17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCT007093 grouped by LRRC17-low versus LRRC17-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC17→partner) and Y-score (partner→LRRC17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CCT007093 →	+0.311	+2.871	.027	.021	3	1
LARGE_INTESTINE	LCL161 →	+0.399	+2.868	.008	.022	3	1
LARGE_INTESTINE	Zoledronate →	+0.264	+2.871	.048	.021	3	1
LARGE_INTESTINE	Savolitinib →	+0.408	+3.000	.015	.017	3	1
LARGE_INTESTINE	Zibotentan →	+0.240	+2.874	.011	.021	3	1
LARGE_INTESTINE	Selisistat →	+0.192	+2.874	.044	.021	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

CCT007093 by LRRC17 expression — LARGE_INTESTINE

Explore this box plot interactively →