LRRC14B

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, LRRC14B mutation is significantly associated with the RNA expression of many other genes, with 553 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRC14B-associated genes across cancer lineages are MIR7-2, FAM32DP, and SNRPFP3. Each is linked with LRRC14B in more than 2 cancer types. Because this analysis shows association rather than direction, both LRRC14B-to-partner and partner-to-LRRC14B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC14B→partner) and Y-score (partner→LRRC14B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
SKCMMIR7-2 →+0.331+4.614<.001.00633
BLCAFAM32DP →+0.093+5.040<.001.00232
LGGSNRPFP3 →+0.154+7.977<.001.00732
SKCMH2AZP5 →+0.120+4.075<.001.00432
SKCMADI1P1 →+0.060+4.282<.001.00932
SKCMRN7SL549P →+0.178+4.744<.001.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 553 associations by consensus.

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