Across TCGA patient cohorts, LRRC14B mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRC14B-associated genes across cancer lineages are JNK_pT183_Y185, p62 Lck ligand, and ACVRL1. Each is linked with LRRC14B in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC14B-to-partner and partner-to-LRRC14B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC14B→partner) and Y-score (partner→LRRC14B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.242	-3.000	.006	.036	3	1
UCEC	p62 Lck ligand →	+0.634	+2.817	<.001	.036	3	1
UCEC	ACVRL1 →	-0.145	-2.980	.043	.036	2	1
UCEC	Shc_pY317 →	-0.192	-3.000	.015	.036	2	1
UCEC	AR →	-0.480	-3.321	.014	.010	2	1
UCEC	VHL →	-0.834	-3.000	.019	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Exploration

LRRC14B survival (RNA) · tumor vs normal (RNA) · all LRRC14B data types