Across TCGA cell cohorts, LRRC14B mutation is significantly associated with the RNA expression of many other genes, with 42 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LRRC14B-associated genes across cancer lineages are OR2V2, TMEM95, and CLDN34. Each is linked with LRRC14B in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC14B-to-partner and partner-to-LRRC14B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC14B→partner) and Y-score (partner→LRRC14B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR2V2 →	+0.044	+3.091	<.001	.006	3	2
BLOOD_Leukemia	TMEM95 →	+0.010	+3.269	.008	.007	3	2
BLOOD_Myeloma	CLDN34 →	+0.043	+4.807	<.001	.006	3	1
BLOOD_Myeloma	FRRS1L →	+0.040	+4.807	<.001	.006	3	1
BLOOD_Leukemia	IL4 →	+2.468	+4.270	<.001	<.001	3	1
BLOOD_Leukemia	HRG →	+0.265	+3.177	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

Exploration

LRRC14B survival (RNA) · tumor vs normal (RNA) · all LRRC14B data types