LRRC14

Across TCGA pan-cancer cohorts, LRRC14 mass-spec protein differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of LRRC14’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where LRRC14 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types LRRC14 is over-expressed in tumor, although a few such as COAD and LSCC show the opposite, repressed pattern.

COAD and LSCC are the cancer types where LRRC14 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LRRC14 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	II,III,IV	−0.315	<.001	10	view →
LSCC	All	III,IV	−0.242	<.001	8	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

LRRC14–COAD

Open the COAD breakdown →