LRRC1

Across TCGA pan-cancer cohorts, LRRC1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated LRRC1 data layer compared with 29 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher LRRC1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated LRRC1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LSCC show a favorable association.

CCRCC, LSCC, and COAD are the cancer types where LRRC1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Quartile	III,IV	0.856	0.210	<.001	33	view →
LSCC	OS	Median	All	1.000	0.923	.012	15	view →
COAD	DFS	Median	All	1.000	0.885	.018	12	view →
GBM	OS	Median	All	0.759	0.952	.003	4	view →
HNSC	DFS	Quartile	IV	0.511	0.819	.009	2	view →
UCEC	DFS	Tertile	All	0.940	0.759	.022	2	view →
LUAD	DFS	Quartile	II,III,IV	0.363	0.671	.033	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

LRRC1–CCRCC (OS)

Open the CCRCC breakdown →