LRRC1

Across TCGA patient cohorts, LRRC1 mutation is significantly associated with the RNA expression of many other genes, with 2,225 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRC1-associated genes across cancer lineages are FEN1, MCMBP, and CLSPN. Each is linked with LRRC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both LRRC1-to-partner and partner-to-LRRC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FEN1 grouped by LRRC1-low versus LRRC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC1→partner) and Y-score (partner→LRRC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FEN1 →	+0.647	+2.091	<.001	<.001	3	3
SKCM	MCMBP →	+0.693	+3.745	.002	<.001	3	3
SKCM	CLSPN →	+0.760	+2.591	.007	.006	3	3
UCEC	POC1A →	+0.453	+2.058	.007	<.001	3	3
UCEC	CDT1 →	+0.838	+2.410	<.001	<.001	3	3
UCEC	TSR1 →	+0.412	+2.119	.002	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,225 associations by consensus.

FEN1 by LRRC1 expression — UCEC

Explore this box plot interactively →