LRRC1

Across TCGA cell cohorts, LRRC1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,918 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LRRC1-associated GO terms across cancer lineages are ERBB3 signaling pathway, ERBB2-ERBB3 signaling pathway, and UDP-galactose transmembrane transport. Each is linked with LRRC1 in more than 11 cancer types. Because this analysis shows association rather than direction, both LRRC1-to-partner and partner-to-LRRC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERBB3 signaling pathway grouped by LRRC1-low versus LRRC1-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC1→partner) and Y-score (partner→LRRC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ERBB3 signaling pathway →	+0.205	+1.388	<.001	<.001	3	12
BREAST	ERBB2-ERBB3 signaling pathway →	+0.205	+1.388	<.001	<.001	3	12
LUNG_NSCLC_LUAD	UDP-galactose transmembrane transport →	+0.144	+1.004	<.001	<.001	3	11
OESOPHAGUS	Cardiac muscle cell-cardiac muscle cell adhesion →	+0.223	+1.082	.008	.003	3	11
URINARY_TRACT	Establishment of epithelial cell apical/basal polarity →	-0.269	-1.440	<.001	<.001	3	10
URINARY_TRACT	Response to indole-3-methanol →	+0.174	+1.038	<.001	.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,918 associations by consensus.

ERBB3 signaling pathway by LRRC1 expression — BREAST

Explore this box plot interactively →