LRRC1

Across TCGA cell cohorts, LRRC1 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible LRRC1-associated genes across cancer lineages are GPR171, DEFB118, and OR2V2. Each is linked with LRRC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC1-to-partner and partner-to-LRRC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPR171 grouped by LRRC1-low versus LRRC1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC1→partner) and Y-score (partner→LRRC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GPR171 →	+0.017	+3.688	<.001	.002	3	1
LUNG_NSCLC_LUAD	DEFB118 →	+0.010	+5.266	<.001	.001	3	1
LUNG_NSCLC_LUAD	OR2V2 →	+0.032	+4.544	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

GPR171 by LRRC1 expression — LARGE_INTESTINE

Explore this box plot interactively →