LRR1

Across TCGA patient cohorts, LRR1 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRR1-associated genes across cancer lineages are EGFR_pY1068, JNK_pT183_Y185, and Paxillin. Each is linked with LRR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRR1-to-partner and partner-to-LRR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by LRR1-low versus LRR1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRR1→partner) and Y-score (partner→LRR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.286	-3.584	.018	.002	3	1
UCEC	JNK_pT183_Y185 →	-0.197	-3.571	.015	.002	3	1
UCEC	Paxillin →	+0.271	+2.820	.030	.035	3	1
UCEC	AMPK_pT172 →	+0.425	+2.472	.032	.011	3	1
UCEC	Rab11 →	-0.173	-3.302	.013	.010	3	1
UCEC	Shc_pY317 →	-0.176	-2.459	.016	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

EGFR_pY1068 by LRR1 expression — UCEC

Explore this box plot interactively →