LRR1

Across TCGA cell cohorts, LRR1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,226 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LRR1-associated GO terms across cancer lineages are Protein localization to kinetochore, Immunoglobulin heavy chain V-D-J recombination, and Regulation of spindle checkpoint. Each is linked with LRR1 in more than 18 cancer types. Because this analysis shows association rather than direction, both LRR1-to-partner and partner-to-LRR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein localization to kinetochore grouped by LRR1-low versus LRR1-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LRR1→partner) and Y-score (partner→LRR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Protein localization to kinetochore →	+0.183	+1.495	<.001	<.001	3	19
OESOPHAGUS	Immunoglobulin heavy chain V-D-J recombination →	+0.221	+1.309	<.001	<.001	3	19
URINARY_TRACT	Regulation of spindle checkpoint →	+0.137	+1.019	<.001	<.001	3	19
OESOPHAGUS	Protein localization to condensed chromosome →	+0.215	+1.497	<.001	<.001	3	19
OESOPHAGUS	Regulation of nuclear division →	+0.121	+1.364	.002	<.001	3	18
KIDNEY	Protein localization to chromosome, centromeric region →	+0.142	+0.868	.001	.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,226 associations by consensus.

Protein localization to kinetochore by LRR1 expression — OESOPHAGUS

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