LRR1

Across TCGA cell cohorts, LRR1 mutation is significantly associated with the mutation status of many other genes, with 3,558 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LRR1-associated genes across cancer lineages are N4BP2, ADCYAP1R1, and RAPGEF3. Each is linked with LRR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRR1-to-partner and partner-to-LRR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, N4BP2 grouped by LRR1-low versus LRR1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRR1→partner) and Y-score (partner→LRR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	N4BP2 →	+2.823	+3.665	.008	.008	1	2
BLOOD_Leukemia	ADCYAP1R1 →	+4.560	+4.309	.007	.007	1	2
LARGE_INTESTINE	RAPGEF3 →	+3.874	+4.215	<.001	<.001	1	2
LARGE_INTESTINE	KIF22 →	+2.652	+3.471	.004	.004	1	2
BLOOD_Leukemia	IGSF9B →	+2.823	+3.665	.008	.008	1	2
LARGE_INTESTINE	CDKL5 →	+2.652	+3.471	.004	.004	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,558 associations by consensus.

N4BP2 by LRR1 expression — BLOOD_Leukemia

Explore this box plot interactively →