LRP8

Across TCGA pan-cancer cohorts, LRP8 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated LRP8 data layer compared with 25 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher LRP8 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated LRP8 expression acts as an unfavorable survival marker, although some lineages such as GBM and LUAD show a favorable association.

GBM, HNSC, and LUAD are the cancer types where LRP8 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	DFS	Quartile	All	0.827	0.561	<.001	12	view →
HNSC	OS	Tertile	All	0.563	0.841	.014	10	view →
LUAD	OS	Median	All	1.000	0.858	.024	4	view →
LSCC	OS	Median	All	0.690	0.889	.013	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

LRP8–GBM (DFS)

Open the GBM breakdown →