LRP8

Across TCGA patient cohorts, LRP8 protein abundance is significantly associated with the RNA expression of many other genes, with 5,095 significant associations in total. GBM shows the largest number of these associations.

The most reproducible LRP8-associated genes across cancer lineages are NIPA1, NECAB2, and UCHL1. Each is linked with LRP8 in more than 2 cancer types. Because this analysis shows association rather than direction, both LRP8-to-partner and partner-to-LRP8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LRP8 versus NIPA1 in BRCA, with a Pearson correlation of 0.62.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRP8→partner) and Y-score (partner→LRP8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NIPA1 →	+0.792	+0.947	.007	<.001	3	3
LSCC	NECAB2 →	+1.658	+0.408	<.001	<.001	3	3
HNSC	UCHL1 →	+2.183	+0.399	<.001	.001	3	3
LSCC	MTARC1 →	+0.862	+0.499	.001	<.001	3	3
GBM	RAP1GAP →	+1.192	+0.432	<.001	<.001	3	3
LSCC	FBL →	+0.657	+0.329	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,095 associations by consensus.

LRP8 vs NIPA1 — BRCA

Explore this scatter interactively →